Altered Expression of RET Proto-oncogene Product in Prostatic Intraepithelial Neoplasia and Prostate Cancer

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منابع مشابه

Altered expression of RET proto-oncogene product in prostatic intraepithelial neoplasia and prostate cancer.

BACKGROUND The RET proto-oncogene encodes a protein that belongs to the tyrosine kinase growth factor receptor family. Germline point mutations in RET are found in individuals with multiple endocrine neoplasia (MEN) syndromes, and gene rearrangements have been reported in papillary thyroid cancers. We recently identified transcripts of the RET proto-oncogene in human prostate cancer xenografts ...

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Prostate cancer and prostatic intraepithelial neoplasia: true, true, and unrelated?

It was in 1987 that McNeal and Bostwick first described intraductal dysplasia during a whole-mount pathologic investigation of 100 prostates without cancer and 100 with cancer that were diagnosed in the pre–prostate-specific antigen era. They found foci of dysplasia in 82% of the prostates harboring cancer compared with 43% in those without cancer. Interestingly, both the grade and volume of dy...

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RET proto-oncogene mutations in the diagnosis of medullary thyroid cancer: a review article

Medullary thyroid cancer accounts for 5-10% of thyroid carcinomas. RET proto-oncogene mutations occur in all of the hereditary MTCs and about 66% of the sporadic MTCs. So, the detection of the RET mutations is necessary for rapid and proper diagnosis and treatment. This systematic review seeks to find a comprehensive list of RET gene mutations in the diagnosis of medullary thyroid cancer. The ...

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RET Proto-Oncogene

Hereditary medullary thyroid carcinoma (MTC) is caused by autosomal dominant gain-of-function mutations in the RET proto-oncogene. Associations between specific RET mutations (genotype) and the aggressiveness of MTC and presence or absence of other endocrine neoplasms (phenotype) are well documented. Mutations in six exons (10, 11, 13, 14, 15, and 16) located in either cysteine-rich or tyrosine...

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Chemopreventive Target for Prostate Cancer: Prostatic Intraepithelial Neoplasia

Prostate cancer is one of the most frequently diagnosed malignancies among the male population and the second common cancer-related death worldwide after lung cancer (Jemal et al., 2010). It is estimated that 30% of male older than 50 years are harboring microscopic transformation of adenocarcinoma within the prostate gland. Because of the dramatic rise in the incidence of prostate cancer with ...

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ژورنال

عنوان ژورنال: JNCI Journal of the National Cancer Institute

سال: 1998

ISSN: 0027-8874,1460-2105

DOI: 10.1093/jnci/90.7.519